DHEA-S - Female

Introduction

As a Florida-based functional medicine nurse practitioner, I’ve seen how mastering key biomarkers enhances women’s health. Dehydroepiandrosterone sulfate (DHEA-S) is the most abundant circulating steroid, produced in the adrenal cortex, and serves as a reservoir for testosterone, estrogen, and progesterone synthesis. In this overview, we’ll explore its roles, clinical implications, ideal ranges, and testing considerations.

The Role of DHEA-S in Female Health

• Hormone Precursor & Anabolic Support
  DHEA-S fuels sex hormone production, supporting muscle repair, skin integrity, and sexual function.
  
• Immune Modulation
  By countering excessive cortisol, DHEA-S enhances immune function, boosting resistance to infections and reducing allergy risk.
  
• Bone & Heart Protection
  It stimulates bone health and helps lower LDL cholesterol, contributing to cardiovascular function.

   

Clinical Implications of Abnormal Levels

Low DHEA-S

Reduced levels often reflect adrenal insufficiency, leading to:

• Hormonal Imbalance: Fatigue, low libido, and mood swings
  
• Insulin Resistance: Hyperinsulinemia suppresses DHEA-S
  
• Compromised Immunity: Lower sIgA output weakens mucosal defenses

   

Longevity studies also link low DHEA-S to age-related conditions like osteoporosis, metabolic syndrome, and mood disorders.

High DHEA-S

Elevations may signal adrenal hyperplasia or excessive androgen precursor activity, potentially disrupting menstrual regularity and contributing to hirsutism.

Optimal DHEA-S Ranges

• Standard Female Range: 18–391 µg/dL
  
• Optimal Functional Range: Top third (≈ 275–391 µg/dL) to mirror youthful 30-year-old levels

   

Maintaining DHEA-S within this narrow window supports anti-aging effects and hormonal equilibrium.

Factors Affecting DHEA-S Measurements

• Supplement Use: Exogenous DHEA skews results—always confirm prior intake.
  
• Medications: Corticosteroids can lower DHEA-S, while androgenic drugs may raise it.
  
• Chronic Stress: The Cortisol : DHEA-S ratio is a key stress marker; a high ratio indicates prolonged adrenal strain and immune compromise.

   

Testing and Interpretation Tips

• Time blood draws consistently (ideally morning).
  
• Review medication and supplement history.
  
• Combine DHEA-S with adrenal and sex hormone panels for a comprehensive picture.

   

In conclusion, a detailed assessment by a functional medicine practitioner in Florida integrates DHEA-S into holistic care. By combining precise biomarker profiling, tailored nutrition, and lifestyle strategies, this approach targets root imbalances rather than merely treating symptoms. Prioritizing cellular health builds resilience, preventive care, and longevity. Explore our Peptide Therapy service to support your hormonal balance and wellness journey.

Further Reading

• Davis, S. R., Wahlin-Jacobsen, S. (2022). Should Dehydroepiandrosterone Be Administered to Women? Endocrine Reviews, 43(2), 245–273. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113789/

• Stuenkel, C. A. (2021). Prescribing testosterone and DHEA: The role of androgens in women. Cleveland Clinic Journal of Medicine, 88(1), 35–44. https://www.ccjm.org/content/88/1/35

• Labrie, F., Archer, D. F., Bouchard, C., Fortier, M., Cusan, L., Gomez, J. L., … & Montesino, M. (2009). Dehydroepiandrosterone: a springboard hormone for female sexuality. Fertility and Sterility, 77(Suppl 4), S19–S25. https://www.sciencedirect.com/science/article/pii/S0015028202029874

• MedlinePlus. (2023). DHEA Sulfate Test: MedlinePlus Medical Test. MedlinePlus. https://medlineplus.gov/lab-tests/dhea-sulfate-test/