Toxicity

Understanding Toxicity: A Functional Medicine Perspective on Environmental Health

Authored by Chris McDermott, APRN, practicing with autonomous authority in Florida

Introduction

In today’s modern world, we are surrounded by thousands of synthetic chemicals, heavy metals, and environmental pollutants that our bodies were never designed to process. Over time, repeated exposure to these substances can overwhelm the body’s natural detoxification pathways, resulting in what we refer to clinically as toxicity.
At Intercoastal Health, we apply a functional medicine practitioner approach—integrating advanced biomarkers and root-cause analysis—to uncover toxic burden, restore detox function, and support whole-body resilience through personalized care.

What Is Toxicity?

Toxicity refers to the accumulation of harmful substances—environmental (e.g., Heavy Metals), biological (e.g., mold mycotoxins), or synthetic chemicals—in the body at levels that interfere with normal physiology. While the liver, kidneys, lymphatics, skin, and gut work to eliminate toxins, chronic or high-level exposure can exceed their capacity, leading to tissue damage, inflammation, and multi-system dysfunction.

Symptoms of Toxicity: Recognizing the Silent Burden

Symptoms of toxic burden are often nonspecific and may be misattributed:

  • Persistent fatigue or low energy
  • Headaches and migraines
  • Digestive disturbances: bloating, gas, constipation
  • Skin issues: eczema, rashes, hives
  • Mood changes: anxiety, depression, irritability
  • Brain fog and memory difficulties
  • Hormonal imbalances: irregular periods, low libido, thyroid dysfunction
  • Increased sensitivity to chemicals
  • Poor immune function: frequent colds, chronic infections

Diagnosing Toxicity: A Functional Medicine Evaluation

  1. Detailed Exposure History
    We review occupation, home environment, diet, travel, and personal care products to identify sources like mold, contaminated water, industrial pollutants, or dental amalgams.
  2. Biomarker-Based Testing
    • Heavy metal panels (blood, urine, or hair)
    • Organic Acids Test (mitochondrial dysfunction, gut dysbiosis)
    • Glutathione status: Evaluates the body’s master antioxidant and detoxifier via Glutathione – Total.
    • Liver and kidney function: Ensures primary detox organs are optimized.
    • Genetic testing: Identifies polymorphisms (e.g., MTHFR, COMT, GST) that impair detox pathways.
  3. Symptom Scoring
    Validated questionnaires help gauge symptom patterns and trigger advanced testing when needed.

Key Biomarkers

Test

Interpretation

Glutathione – Total

Master antioxidant status; low levels suggest impaired Phase II detox

Anion Gap

Elevated in metabolic acidosis; may correlate with toxin-induced mitochondrial stress

Lactic Acid

Marker of anaerobic metabolism; elevated in mitochondrial dysfunction from toxic overload

Magnesium – Serum

Cofactor for detox enzymes; deficiency impairs Phase I and Phase II liver pathways

Cortisol – Total/AM

Chronic stress hormone that can exacerbate oxidative stress and toxin sensitivity

Common Sources of Toxicity

  1. Heavy Metals
    • Lead (old pipes, paints, spices)
    • Mercury (large fish, dental amalgams)
    • Arsenic (groundwater, rice)
    • Cadmium (batteries, smoke)
  2. Environmental Chemicals
    • Pesticides on produce
    • BPA and plastics in food containers
    • Phthalates/parabens in personal care products
    • VOCs from paints and cleaners
  3. Biological Toxins
    • Mold/mycotoxins in water-damaged buildings
    • Bacterial endotoxins from gut dysbiosis
  4. Pharmaceuticals
    • NSAIDs, acetaminophen, statins, some antibiotics, and chemotherapy agents increase liver burden

Clinical Implications of Toxic Burden

Unaddressed toxicity contributes to:

  • Neurodegenerative diseases (Alzheimer’s, Parkinson’s)
  • Autoimmune disorders (Hashimoto’s, lupus)
  • Hormonal imbalances (thyroid dysfunction, PCOS)
  • Cardiovascular disease (hypertension, atherosclerosis)
  • Cancers (mutagenic chemical effects)
  • Mitochondrial dysfunction (fatigue, metabolic issues)
  • Developmental delays in children (lead, mercury exposure)

Functional Medicine Detoxification: A Personalized Protocol

Step 1: Reduce Exposure

  • Choose organic produce
  • Use air and water filters
  • Eliminate plastics and synthetic fragrances
  • Avoid inflammatory foods

Step 2: Support Detox Organs

  • Liver: B vitamins, N-acetylcysteine (NAC), IV therapy infusions of glutathione and cofactors
  • Kidneys: Hydration, electrolytes, and kidney-supportive herbs
  • Gut: Address dysbiosis and promote regular elimination
  • Skin: Infrared sauna, dry brushing for lymphatic support

Step 3: Correct Nutrient Deficiencies

  • Magnesium, zinc, selenium, sulfur-rich foods (garlic, onions, crucifers)

Step 4: Targeted Supplementation

  • Binders: Activated charcoal, bentonite clay
  • Antioxidants: Vitamin C, alpha-lipoic acid, glutathione
  • Chelation: Under supervision for heavy metals

Monitoring Progress

We track outcomes via:

  • Symptom scales and quality-of-life surveys
  • Repeat biomarkers (e.g., heavy metal levels, glutathione status)

Nutrient repletion labs
Patients typically report improved energy, clarity, mood, and resilience.

Further Reading

In conclusion, a comprehensive evaluation by a functional medicine practitioner in Florida identifies cellular and molecular imbalances driving toxic burden. By integrating evidence-based nutrition therapy with IV therapy and Regenerative Medicine services—where rapid nutrient delivery and tissue support are paramount—we offer a regenerative, preventive framework to rebuild detox pathways, reduce inflammation, and restore vitality. Call (904) 799-2531 or schedule online to request your personalized toxicity assessment.

Board Certified & Professional Member of

American Academy of Nurse Practitioners
Florida Association of Nurse Practitioner
The American Association of Nurse Practitioners
American Academy of Anti-Aging Medicine
International Association of Rehabilitation Professionals

Schedule your visit today!

Ready to take the next step in optimizing your health? Contact us to schedule a comprehensive functional medicine evaluation centered on whole-person care. We offer convenient in-person and telemedicine appointments. Our team is available to assist with scheduling and to ensure you receive the support and care you need.

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